Sentence examples for therefore disrupted from inspiring English sources
The continuous nature of the endomembrane system means that disruption of one component will have downstream effects upon others, and therefore disrupted secretion upon EspG overexpression may be a secondary effect of disrupted recycling during EHEC infection.
The upward trend from 2008 to 2011 was therefore disrupted [62].
When a fibular segment is removed in these areas, the main source of blood supply (nutrient artery) to the periosteum is therefore disrupted and ischaemia leads to failure of regeneration in the defect.
We therefore disrupted caveolae structure by underexpressing cav-1.
Therefore, disrupted T cell development occurs even with the endogenous TCRα locus if it has already undergone rearrangement [8].
Therefore, disrupted Erb B2 signaling might contribute to the axonal degeneration and SC demyelination in diabetic nerves.
Therefore, disrupting Bcr Abl oligomerization represents a potential therapeutic strategy for inhibiting Bcr Abl oncogenicity.
Genetic alterations of individual PSD scaffolds therefore disrupt the function of entire multiprotein modules rather than a single glutamatergic mechanism, and thus induce a range of molecular and structural abnormalities in affected neurons.
Therefore, disrupting E6 linkage to p53 and liberating p53 in those HPV-infected cells may restore their altered biological functions and allow cells to continue the normal process of cell apoptosis.
Several peptide derivatives, 2, 7 and 8, showed modest but significant binding affinity, indicating that the designed peptide could mimic the VEGF81 91 fragment and therefore disrupt the VEGF/VEGFR-1 interaction.
The TbPEX5 structures reported here reveal a unique hydrophobic pocket in the subdomain interface that might be explored to obtain compounds that prevent relative motions of the subdomains and interfere selectively with PTS1 motif binding or release in trypanosomatids, and would therefore disrupt glycosome biogenesis and prevent parasite growth.
