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Furthermore, the inevitable dose reductions and delays in bexarotene reduce dose intensity and therefore detract from the potential increased efficacy of using this combination of drugs.
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31, 32 This, therefore, detracts from the conventional notion that PDK1 is merely an Akt-activating stepping stone, but rather it highlights the notion that PDK1 may be an important oncogenic regulator and a potential therapeutic target in cancer.
The mayor's office said the Caribbean Showcase would be aimed at up to 5,000 people, primarily families who would not normally attend the carnival, and would therefore not detract from the main festivities.
Smith's early parliamentary commitments in Salisbury therefore did not detract greatly from his ranching.
It said the laws therefore "do not impair, undermine or detract from the institutional integrity of the Northern Territory courts".
However on Wednesday, a majority of the high court bench rejected the assertions the scheme gave the NT executive powers that were "penal or punitive in character" and said the laws therefore "do not impair, undermine or detract from the institutional integrity of the Northern Territory courts".
Residents, medical students and interns require differing amounts of the attending physician's time which detracts from the patient, therefore it would be important to incorporate these staff members in the model to more precisely measure physician utilization.
The incorporation of these and other design features may promote or detract from perceptual proximity and therefore influence a display's usability.
There would also be a massive expectation that he would win, so therefore you have to get ready and do it properly and that detracts focus".
Therefore, the fact that dose escalation of infliximab was not permitted in the double-blind period should not detract from these findings.
Even the fact that much of the story is set on a spaceship and is therefore heavy on the kind of Dr Who -type noises made by 10-year-old boys somehow doesn't detract.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com