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With blocking the proteasome, the impact of torsinA on G85R SOD1 protein levels was therefore abolished.
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This force activates stretch-sensitive calcium specific ion channels which can be inhibited by the addition of gadolinium which therefore abolishes gravitaxis.
If TAT is required for the lytic activity of TMR-TAT, degradation of the peptide should therefore abolish the activity of the compound.
The loss of Fas therefore abolishes the activation of its downstream apoptotic signaling including the activation of caspases in PrCa.
Comorbid anxiety in depression may therefore abolish the low arousal and lead to increased activity in the attention network.
Random rearrangements of RIDGEs and anti-RIDGEs, on the other hand, would reduce the clustering of genes, and therefore abolish the effect of regional regulation of transcription.
The BH3-mimetic HA14-1 blocks the ability of Bcl-2 to bind and neutralize Bax and should therefore abolish the beneficial effect of S118Bad phosphorylation.
Inhibition of Na+/H+ exchange by removal of extracellular Na+, prevents the enterocyte from maintaining intracellular pH (pHi) during H+/solute influx and, therefore, abolishes the driving force (the transmembrane H+ electrochemical gradient) for further transport.
Therefore abolishing the palmitoylation of PMP22 slows the maturation of newly synthesized protein; however, it does not block its processing through the secretory pathway.
Homophobic discrimination is wrong and should therefore be abolished pronto.
Therefore, we abolished the unique macromolecular poration properties of MelP5 by introducing pH sensitivity into its sequence.
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