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Therefore, a weakness of this study is the lack of samples to test independently the performance on stage I disease.
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The fact that several datapoints lie outside the confidence interval for the mean does not therefore represent a weakness of our model.
The lack of validation of endpoints is therefore a weakness in our study, even though we performed separate analyses on overall and deep infections without any major changes in risk assessment.
Obesity is therefore sometimes conceived of as a weakness of character [ 56, 57] or a weakness of the will (akrasia).
Although the quality of life utilities reported from CODE-2 were specific for European patients with type 2 diabetes the utilities were based on 4,641 study participants from Belgium, Italy, Netherlands, Spain and Sweden, and therefore a potential weakness of the current study is that these may not be representative of attitudes among German patients.
Systematic reporting of HIV cases in Italy is limited to a few areas (Centro Operativo AIDS, 2008), and therefore a major weakness of our present study is reliance on AIDS case reporting only.
Therefore, in order to overcome such a weakness of the fibrous composites, it is very important to understand the stress relations between constituent materials of a hybrid composite rotor with respect to their dimensional parameters and material properties.
We therefore do not believe that it was a weakness of this study that only one of the authors screened the initial records for suitable articles.
A weakness of this study was therefore the lack of preparticipation screening and appropriate exclusion criteria.
Conversely, interpretation can be a weakness of this method and reliability can be compromised, therefore inter-coder agreements are required.
A weakness of the study is that the sample in some subgroup analyses was limited, and may therefore limit the possibility of statistically significant results.
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