Sentence examples for thereby up from inspiring English sources

Exact(1)

Direct evidence about the involvement of PC-1 in cell cycle regulation was demonstrated by the observation that PC-1 overexpression activates the JAK2/STAT-1 patherebythereby up regulating p21waf1 and inducing cell cycle arrest in G0/G1 in a process requiring functional polycystin-2 (PC-2).

Similar(59)

Maybe so, though the Fed, at least, looks likely to ease further, thereby upping the pressure on China to revalue.

During ischemic injury, activated AMPK suppressed mammalian target of rapamycin (mTOR) by phosphorylation, thereby up-regulate autophagy, to play a protective effects on cell survival during ischemia (Takagi et al., 2007).

We show that such enhancement in neurogenesis is achieved by altering global gene expression profile thereby up-regulating cell adhesion through intracellular calcium influx and activated focal adhesion kinase signaling pathway, which is stimulated by extracellular matrix production.

Namely, how once out on the Internet every government and malicious hacker actor would be able to copy and learn its sophisticated malware techniques, thereby upping the game and stakes in the global cyber arms race.

This was some years ago, when women were just beginning their upward climb on the crime ladder, with Patty Hearst and later Kathy Boudin becoming radicalized and going into major crimes (kidnapping, murder, bombing), thereby upping the ante on brains and looks.

The two main criticisms of using microwaves go like this: that the convenient device a) produces radiation in your food and outside of the appliance, thereby upping your cancer risk, and/or b) zaps all the nutrients out of your food.

Recent findings have shown that Hsp70 binds various Toll-like receptors (TLRs) and elicits a rapid intracellular Ca2+ flux, activate NF-κB and thereby up-regulate the expression of pro-inflammatory cytokines and chemokines [22], [23], [24], [25], [26].

Therefore, glutamate may act at the NMDA receptor site on brain endothelial cells to enhance calcium influx thereby up-regulating eNOS, to cause the formation of NO and the subsequent generation of ONOO−.

Another group reported that the increase in STAT3 activation in the MCT-injected rat model decreased the expression of miR-204, which thereby up-regulated the activation of STAT3 and NFAT, thus allowing PASMC proliferation and resistance to apoptosis (Courboulin et al, 2011).

Upon Ire1p activation, the Ire1p RNase initiates the splicing of a non-conventional intron from HAC1 messenger RNA (mRNA), thus allowing the translation of active Hac1p, a basic-leucine zipper (bZIP) transcription factor that specifically binds to UPR elements (UPREs) in the promoter region of UPR target genes, thereby up-regulating their transcription [ 25, 26].

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