Sentence examples for thereby to activate from inspiring English sources

It is known that ZF's 6-13 constheute the DNA-binding domain of hOAZ, which is however lacking the ability to interact with SMAD's and thereby to activate target promoters [13].

IL-6 was shown to activate STAT3, even in the presence of TGF-beta1, and thereby to activate proliferative and anti-apoptotic pathways.

Thus, loss-of-function NKX2.1 mutations result in haploinsufficiency, and the resultant mutant protein has altered DNA-binding properties and is thereby unable to activate target genes.

The deacetylated BubR1 can be ubiquitinated by the APC/C and consequently degraded, thereby releasing Cc20 to activate the APC/C against its metaphase substrates, cyclin B and securin.

We propose that the mechanism of this activation involves the ROS mediated release of ASK1 from an (SH 2Trx-ASK1 complex thereby enabling ASK1 to activate the p38 MAPK and SAPK/JNK pathways [ 13, 18- 23, 23].

SIRT1 can also interact with and deacetylate numerous transcription factors, thereby modulating their transactivation activity to activate or suppress genes.

Hence, in the presence of thrombin + histamine, thrombin-activated Rho GTPase unfolds ROCK to allow histamine-activated PKG to activate ROCK thereby enhancing the level of ROCK activation in combination with thrombin-mediated Rho GTPase activation of ROCK.

Although not explicitly confirmed in this study, the authors inferred that the mutants either affected the catalytic activity or expression levels of CPR, thereby reducing its ability to activate paraquat.

The authors have used elutriation to enrich for specific cell cycle phases thereby obviating the need to activate cell cycle checkpoints to synchronise cells.

When ER stress occurs, Bip preferentially binds to aberrantly folded proteins that accumulate in the ER, thereby freeing the sensors to activate their signaling pathways.

Ubiquitination subsequently promotes the association of H- and N-Ras with the endosomes, thereby modulating the capacity to activate the Raf/ERK pathway [ 43].