Among the more than 4,700 chemicals of cigarette smoke, reactive compounds oxidatively modify cellular proteins, thereby seriously challenging the proteostasis network of the cell.
For every design change, these components need to be remodeled and their reduction bases recomputed, thereby seriously hindering the effectiveness of the CMS approach.
Alterations in traditional land use practices have led to severe declines in the area of semi-natural grasslands, thereby seriously threatening plant and animal species dependent on these habitats.
In thin-walled I-sections the horizontal shear stress can produce shear distortions of sufficient magnitude to redistribute the direct stresses due to bending, thereby seriously affecting the accuracy of the basic bending theory.
PSP has major implications to public health and thereby seriously threatening economic consequences in coastal communities and aquaculture industries worldwide.
However, conventional MRI techniques cannot resolve the various bladder wall layers accurately, thereby seriously limiting the accuracy of T staging, particularly in distinguishing among muscle invasive (stage T2 or higher) and superficial (stage T1 or lower) tumours.
However, the existence of incongruity barriers often makes many water lotus crosses difficult, and thus raising hybrids may be hard to achieve, thereby seriously reducing the breeding efficiency [ 7].
Remarkably, child and parent report data indicated that in about half of the children fear of spiders had always been present, thereby seriously questioning the importance of learning experiences such as threat information transmission in the etiology of this type of fear.
