Sentence examples for thereby sensitizing it from inspiring English sources

First, severe pain from an injury or other stimulus, if continued over some period, was found to alter the neurochemistry of the central nervous system, thereby sensitizing it and giving rise to neuronal changes that endure after the initial stimulus is removed.

SIRT1 deacetylates the RelA/p65 subunit of NF-κB at Lys310 and represses its transcription activity, thereby sensitizing cells to TNF-α-induced apoptosis.

One possibility is that caspase-8 inactivates RIP1 through proteolytic cleavage, and its suppression enhances RIP1 stability, thereby sensitizing cells to RIP1-mediated necrosis.

These investigations support the hypothesis that the aging-associated decline of sAPP α and its neuroprotective function may contribute to this upregulation, thereby sensitizing neurons to apoptosis.

Thimerosal oxidizes thiols to form a thiomercurylethyl complex, thereby sensitizing InsP3 to basal InsP3 levels [ 37].

ETS1 suppresses BRCA1/2 expression and impairs HR, thereby sensitizing the cells to the PARP inhibitor.

Mild hypoxia (3% O2) was found to increase invasion by amplifying HGF signaling, thereby sensitizing cells to HGF stimulation [ 43].

Depletion of MnSOD or NF κB increases the toxic superoxide free radical in suspended cells, thereby sensitizing cells to anoikis.

In addition, HDAC inhibition can suppress the ATM signaling pathway, thereby sensitizing cancer cells to DNA damage (Thurn et al, 2013).

3. The TGF-β1 pseudoreceptor BAMBI [ 20], which is downregulated by a TLR4-MyD88-NF-κB depathway patherebythereby sensitizing HSCs to TGF-β1 signaling.

This suggests that the majority of dislocating RTA is normally degraded and that inhibition of the proteasome leads to higher concentrations of toxin, thereby sensitizing cells.