The antithrombotic experiments showed that polyphosphazene OFP materials reduced human Factor XII activation and platelet adhesion, thereby being resistant to plasma coagulation and thrombosis.
Tumour cells express several proteins that suppress apoptosis and thereby become resistant to various forms of therapy.
In either case, vulnerable cells damaged by ischemia and oxidative stress may have their damaged proteins eliminated by these mechanisms, thereby allowing resistant cells to persist.
Experimental approaches have revealed numerous feedback loops in tumor cells and have shown that blocking one signaling pathway, be it the receptor [ 22, 23] or downstream targets [ 24, 25], is not sufficient to cause tumor regression, thereby allowing resistant cells to emerge.
5) In severely toxic patients, a simultaneous intramuscular dose of 60 mg of Artesunate on each buttock followed by a daily dose of 60 mg for the next 5 days reduces the parasite load as it is relatively new and thereby less resistant and is an effective schizonticide.
Nevertheless, we propose to apply the ILAE Task Force definition for veterinary patients thereby drug-resistant epilepsy is diagnosed if seizure freedom is not achieved with two therapeutic trials.
The existing non-contact latent fingerprint detection systems are bulky, expensive and require environment which is shock and vibration resistant, thereby limiting their usability outside the laboratory.
have shown that various chemotherapeutic treatments activate Rb, resulting in cell cycle arrest and activation of DNA repair mechanisms, thereby rendering cells resistant to chemotherapeutics [ 16– 216.
Increased levels of CHEK1 in tumour cells may therefore provide them with a survival advantage due to the ability to tolerate a higher level of DNA damage and the tumour cells thereby become chemotherapy resistant [ 55].
The promiscuity of P-gp led pharmacologists to posit that drugs unrelated to cancer chemotherapy may 'compete' with anti-cancer drugs for transport and thereby overcome the resistant phenotype, providing a potential clinical strategy.
