Arsenic is believed to exert its toxicity by combining with certain enzymes (the organic catalysts of the cell), thereby interfering with cellular metabolism.
Most carcinogens, singly or in combination, produce cancer by interacting with DNA in cells and thereby interfering with normal cellular function.
The internal market commissioner, Frits Bolkestein, proposed taking legal action, arguing that the Volkswagen law deters potential buyers of the carmaker, thereby interfering with the free movement of capital in the European Union.
In some cases, these chemicals are thought to mimic female sex hormones – oestrogens – and in other cases act as anti-androgens, the male sex hormones, thereby interfering with the male reproductive system.
Nutrient excesses are not common, the major risk being that excesses of one or two nutrients may bind to other nutrients, thereby interfering with their efficient absorption in the digestive tract.
This fact can affect the selection of essential nutrients, thereby interfering with the process of satiation.
Some of them inhibit Ca2+, Mg2+-ATPase, thereby interfering with calcium removal from the nerve endings, resulting in increased neurotransmitter release in the postsynaptic gap.
Zearalenone and its reductive metabolites are a well known set of mycotoxins able to bind estrogen receptors (ERs) thereby interfering with the endogenous estrogenic response.
The program takes advantage of an apparent weakness in the Windows operating system by blocking a computer's ability to get a unique identifying name on a network, thereby interfering with its ability to talk to other machines on the network.
Furthermore significant DNA damage was possibly be due to interaction of silver ions with the DNA of microorganism that leads to the instability of DNA and thereby, interfering with its ability to replicate.
In phase II trial, cecatecarin (570) intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis [293].
