For example, complexes of ß-catenin and TCF/LEF directly bind to upstream transcription regulatory elements of the micropthalmia transcription factor (MITF) gene during embryonic development, thereby instructing premigratory neural crest cells to differentiate into melanocytes (Bachmann, 2005; Dorsky et al, 1998; Larue et al, 2003; Wu et al, 2003).
Maria's role as mother allows her to instruct herself, thereby creating her own sense of self; in advising her daughter through the manuscript she is writing, Maria learns about herself and realizes her past errors.
The builder herself has to instruct the helper, thereby directing him to assist her effectively.
The tenants-at-will thereby enfranchised typically voted as instructed by their landlords, who in turn normally supported the Tory party.
Strachan did not endear himself to his players following the team's 2-0 defeat at West Brom by instructing the team coach to leave early, thereby depriving his squad of the £250 worth of pizzas they had ordered for the journey home.
For the remaining four questions children were explicitly instructed to answer as elaborated as possible thereby providing an index of children's maximal responding.
These data demonstrate that anisotropic fibroblast-derived matrices instruct the alignment and shape of endothelial tube networks, thereby introducing an approach that could be adapted for future design of microvascular implants featuring organ-specific natural matrix that patterns microvascular growth.
bFGF-hFLSCs feeder cells were central to establishing the signaling network among bFGF, IGF-2, and TGF-β, and thereby probably providing the framework in which hES cells were instructed to self-renew or to differentiate.
Patients were thereby exposed to a standardized horizontal unidirectional oscillatory stimulus and instructed to dampen the movement of the platform as quickly as possible to return to quite standing.
The Sierra Leone ministry of health refused to share data in the early outbreak and instructed the WHO to report only lab-confirmed deaths, thereby excluding the "probable" and "suspect" cases that could not be tested because of the lack of testing facilities.
