Myeloma cells also produce RANKL or RANKL-inducing molecules thereby initiating the classical vicious cycle of tumor-initiated osteolysis [ 24].
Back in 1962, a young man named Nigel Potter arrived in Glasgow from London to start voluntary work in an approved school, thereby initiating what became Community Service Volunteers, later CSV.
Soon after the Gulf war of 1991, the first President Bush convened a summit of Arabs and Israelis in Madrid, thereby initiating a decade of peacemaking.
As a myxamoeba moves across a moist surface, it engulfs bacteria and eventually fuses with a second myxamoeba, thereby initiating the development of a multinucleate plasmodium.
Tissue factor forms a complex with factor VIIa to activate factors IX and X, thereby initiating the coagulation protease cascades.
The high-energy particles generated in the plasma can then satisfy the chemical bonding energies on the surface of the tubes thereby initiating chemical reactions.
We hypothesize that higher neurite motility enhances the probability of one neurite to reach a critical length relative to others, thereby initiating the developmental sequence of axon differentiation.
Progression through G1 and transition to S-phase, thereby initiating genome duplication, requires the concerted action of cyclin-dependent kinase (CDK cyclin complexes on specific targets.
He was also responsible for forging the concept of 'nihilism' — a condition of which he accused the philosophers — and thereby initiating the discourse associated with it.
Importantly, these altered patterns of DNA epigenetic marks (e.g. 5-mC, 5-hmC) are frequently accompanied by a critical imbalance in transcriptional programs involving differentiation and stem cell maintenance, thereby initiating tumorigenesis and sustaining growth (Jones and Baylin, 2007).
The complex translocates to the nucleus and binds to the IFN-stimulated response elements (ISREs) present in the promoters of IFN-stimulated genes (ISGs), thereby initiating the transcription of those genes.
