Several ligands including the growth factor pleiotrophin (PTN) bind to RPTPβ and inhibit its phosphatase activity, thereby activating cellular signalling pathways.
Hyperactivation of PARP-1 depleted ATP pools in dopaminergic (DA) neurons, thereby activating AMP-activated protein kinase (AMPK).
When Hh binds to its receptor, Patched (Ptc), repression of the Hh pathway activator Smoothened (Smo) is relieved, thereby activating the Hh pathway[34], [35].
Thought to be important for cell-signaling activity, this surface is made accessible by proteolytic cleavage, thereby activating the cell-signaling function of these enzymes.
For tonight, though, all that matters is that someone on the Marlins hits a home run (Mike — no, make that Giancarlo — Stanton, is the best candidate), thereby activating the feature.
Like other protein hormones, insulin binds to specific receptors on the outer membrane of its target cells, thereby activating metabolic processes within the cells.
First, they might ask students to explore a concept, thereby activating their prior knowledge.
Oxidative stressors can cause Nrf2 to translocate to the nucleus, thereby activating the Nrf2 pathway [21].
By changing the tongue position and thereby activating different sensors, the user sets control commands.
G protein coupled receptors catalyze the GDP/GTP exchange on G proteins, thereby activating them.
The AP-1/c-Jun regulates TGFβ expression thereby activating the TGFβ-NOX axis to further potentiate ROS accumulation.
