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Anti-hypertensive medication was stopped at the time of transplantation and thereafter titrated aiming a BP below 130/8 0mmHg.
Three late-intervention groups (each n = 6) received IV selepressin (1 pmol/kg/min), arginine vasopressin (0.25 pmol [0.1 mU]/kg/min), or norepinephrine (3 nmol [0.5 μg]/kg/min) when mean arterial pressure remained less than 70 mm Hg despite fluid challenge; study drugs were thereafter titrated to keep mean arterial pressure at 70 80 mm Hg.
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The basal insulin dose was kept unchanged for 24 weeks but could thereafter be titrated according to fasting plasma glucose levels at the investigators' discretion.
According to the authors' local practice, epinephrine was started as the first-line vasopressor (0.15 μg/kg/minute) and titrated thereafter to obtain a mean arterial pressure of 65 to 75 mmHg.
In the ASPIRE trial, the efficacy of infliximab (3 or 6 mg/kg infusions at weeks 0, 2 and 6 and every 8 weeks thereafter) plus MTX (titrated up to 20 mg/week by week 4) was assessed in 1,004 MTX-naïve patients with early (≥3 months, ≤3 years), moderate-to-severe active RA over a 54-week period [ 45].
Baseline settings were adjusted according to our routine clinical practice and thereafter PEEP level was titrated to reach a Plat 28 30 cmH2O ("Express" strategy).
Thereafter, the dose was titrated back to target levels over the following 48 hours.
Thereafter, the vasopressor doses were titrated to maintain MAP at 70 80 mm Hg as in the previous experiments, each titration step being maintained for at least 15 minutes.
PEEP was maintained above the closing pressure (mean 25±± 3 cmH2O) for 48 hours and titrated down gradually thereafter to maintain a ratio of partial pressure of oxygen to fraction of inspired oxygen (PaO2 FiO2) greater than 300 mmHg.
Sedative dosing would be titrated every two hours thereafter or sooner if the patient was agitated (that is, SAS ≥ 5).
The antigens were initially titrated in two-fold dilutions from 1 1000 to 8000, and thereafter evaluated in the dilution range of 1 1500 to 1 4000.
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