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First, c-Myc, which controls expression of both genes, was only downregulated in the sFRP1-expressing tumors; second, in the tumors there were major changes in expression of probesets for extracellular matrix proteins.
Not surprisingly, however, there were major changes in the plays during and after Reconstruction.
There were major changes in drainage patterns following the formation of the Cordillera Neo-Volcánica during the second episode.
Abbott said if there were major changes to taxes and government responsibilities "we need to have something approaching a consensus because change ought to be durable".
The CDP is staunchly defended by the federal government and the Indigenous affairs minister, Nigel Scullion, but on Sunday a spokesman said there were major changes proposed.
But Mr. Van Miert quickly raised objections, arguing that the three companies would have clear monopoly power unless there were major changes to the plan.
Similar(42)
There are major changes in their local abundance during different seasons.
"If there are major changes in the ocean, that does affect sea ice, for example," he explained.
And beyond commerce there are major changes at one of the street's cultural landmarks, the Studio Museum in Harlem.
Sjögren's syndrome is essentially an epitheliitis and there are major changes to normal architectural salivary organization.
While the geomagnetic latitude differences are relatively small, there are major changes in the vertical cutoff rigidity values for these same locations over this 150-year period.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com