Our results indicate that there are extensive changes in gene expression in all regions of the brain examined.
Since then there have been extensive changes, most notably the arrival of a new executive chef, Christophe Bellanca, in place of Pierre Schaedelin.
Brian Lightman, general secretary of the Association of School and College Leaders, said: "There have been extensive changes to initial teacher training in recent years with the introduction of School Direct, and we know there have been issues with shortages in some key subjects.
The proposals have yet to be finalised but there will be extensive changes to constituencies across the UK if the plans go ahead.
The home's owners, Castlebeck, said there had been "extensive changes in board and management" and new measures introduced to ensure it could not happen again.
Following the public outcry since 2012 about the more serious forms of these offenses, there have been extensive changes in the Indian Penal Codes in distinguishing sexual harassment behaviors.
Certainly there can be extensive changes in gross biochemical composition as cultures are starved.
Soft synovial tissues were heavily hypertrophic with foci and necrosis, and there were extensive erosive changes.
There were extensive upgrades and substitutions.
There were extensive rodent problems too.
