If one accepts the linear model of differentiation [ 10], which we note has been challenged [ 12], then our findings indicate that in RA there may be an accelerated differentiation of naïve cells into central memory CD4+ and CD8+ T cells.
More generally, there may be regulators of the differentiation programme of mammary epithelial cells, such as GATA3 or TP73L, that are not correctly expressed in the xenografts.
This suggests that there may be a point during cell differentiation when these local gene-silencing events reach a critical mass that is sufficient to give rise to visibly condensed facultative heterochromatin.
Given the important role of alternative splicing in neural differentiation, there may be selective pressure to maintain a majority of splicing events in order to retain glial-like characteristics of the tumor cells.
This small number of common genes is consistent with the idea that there may be important differences in neuronal differentiation at these two developmental stages: the embryonic nervous system is forming de novo, while neurons differentiating in the adult are integrating into an already existing functional nervous system.
There may be various degrees of plasma cell differentiation.
This study identified that the Keratin-15-GFP cells accumulate in number and broadly upregulate a gene-expression signature of undifferentiated stem cells, suggesting that there may be a functional block in the differentiation capacity of these cells in vivo.
Interestingly, the expression of miR-200b/c was decreased during low-differentiation cell enrichment and increased upon differentiation, indicating that there may be negative feedback between miR-200b/c and cholangiocarcinoma stem-like cells.
Because there may be reciprocal effects between OB and adipocyte differentiation [ 36, 37] and because PTH can regulate adipocyte differentiation [ 35], we examined expression of Adiponectin, a marker of adipocytes, and Pparγ, a transcription factor that may be important not only for stimulating adipogenesis but also for suppressing osteogenesis [ 38].
Thus, there may be a Maf code for SGN terminal differentiation, with each factor directing a different feature required for mature function.
