The worksite health promotion intervention from the Netherlands [36] also has a median cost-effectiveness ratio under $50,000 per DALY, but there is substantial uncertainty around intervention effectiveness, leading to only a 50% probability that this intervention will be cost-effective if rolled out in Australia.
However, in the two latter studies there were substantial problems with the implementation of the intervention or loss to follow-up, respectively, and this may have reduced the apparent effectiveness of the interventions [ 17, 18].
There is substantial evidence that dance-movement interventions provide emotional and social advantages.
National self-report surveys have found complementary and alternative techniques such as mindfulness, are being used by 41%to54%4% [ 63] of individuals with depression, indicating that there is substantial public demand for mindfulness-based treatment interventions.
7 There is substantial evidence for the effectiveness of interventions for these conditions.
A further systematic review, which did not attempt a meta-analysis, concluded that while there is substantial evidence that lifestyle or pharmacologic interventions effectively delay or prevent diabetes, there was insufficient evidence to compare their effectiveness [ 128].
59, 60 There is substantial evidence that effectiveness is enhanced when interventions fit easily into people's everyday lives, include awareness-raising tools (eg, accelerometers to monitor PA), and involve various behavioral strategies, such as motivational interviewing and problem-solving techniques.
Indeed, in many HDSSs there is substantial ongoing malaria surveillance along with studies evaluating the impact of malaria interventions.
There is substantial evidence to relate sirtuins to the aging process, age-related diseases, and anti-aging interventions.
There is substantial geographical variation in the use of intensive care resources in Denmark both concerning ICU admissions and intensive care interventions.
There is substantial variation across countries.
