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Preliminary studies from our laboratory suggest that in absence of both of these cytokines there is defective up-regulation of master transcriptional factors, T-bet and Eomes in CD8+ T cells (Figure S5).
In PKU, there is defective hydroxylation of phenylalanine to produce tyrosine.
In pre-eclampsia, there is defective early trophoblastic invasion of the decidua due to failure of conversion of the spiral arteries into low-resistance channels.
Therefore, if there is defective monocyte trafficking, it is unlikely to result from cell-autonomous effects of Slfn4-expressing monocytes, since this transgene is also UAS-dependent.
These repeating elements in genes can be prone to a high rate of mutation if there is defective mismatch repair.
Moreover, the normal fibrillar structure of fibulin-5 was disrupted in the lungs and aortas of both Ltbp-4-deficient mice and replaced by scattered amorphous patches, suggesting that there is defective deposition of fibulin-5 into the ECM (supplementary material Fig. S6B).
Similar(54)
I don't think there are defective generations.
Just like there are defective products out there, there are "defective" experiences in here: unhappiness, alienation, resignation, depression, hopelessness, resentment, shame, remorse, loneliness, dread and others.
Protein expression of PTEN was preserved, but there was defective regulation of PTEN function by the α2β1-polymerized collagen interaction.
Strikingly, when patients with RA were treated with chemotherapeutic regiments, there was defective recovery of both CD4 and CD8 T cell populations, including both naive and memory cells.
In renal allografts, it has been demonstrated that there was defective T-cell priming in the absence of local synthesis of C3 [ 26], suggesting that locally produced C3 is more crucial for acute cellular rejection than the circulating host derived C3.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com