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That patients who received the combination therapy also had 3-factor PCC as their PCC product raises the possibility that there is a true difference between different PCC products.
The fundamental question remains as to whether there is a true difference in potential life years lost for patients of different ages but with the same short-term cardiovascular risk.
I have a background in psychology and am the mother of a 5-year-old who received a diagnosis in January, and the more time we spend with other children on the autism spectrum, the more I sense that there is a true difference, if mainly qualitative.
It is quite possible that there is a true difference between men and women.
Application of the Wald test (which assesses whether there is a true difference between groups) suggested that there was no real difference in the levels between partial and complete remission.
While it is likely that there is a true difference, the authors should be more cautious about making statements of "mosaicism in AD brains", which implies that this is not the case in controls.
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This approach does not require prior knowledge as the investigator should choose the smallest effect size they would be willing to miss (if there was a true difference).
Thirdly, for a distribution such as the log-normal, the SD is partly a function of the mean value; this implies that (when comparing two groups as in a t test) if there really is a true difference in mean values, then the SDs will also differ perhaps substantially.
We still do not know whether race/ethnicity affects only the reporting of excessive salivation (ex: different cultural acceptability), or if there is a true physiological difference between racial/ethnic groups.
The merit in using this model is that it allows determining whether there is a true gender difference.
Although Europeans reported heavier smoking than South Asians and part of the differences observed appeared to be related to differences in cell composition, these factors could not completely account for their lower scores, suggesting that either key aspects of smoking behaviour had not been captured, or that there is a true ethnic difference in methylation response to smoking.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com