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The phrase "there is a sizable difference" is correct and usable in written English.
You can use it when discussing a notable distinction or disparity between two or more items, concepts, or situations. Example: "After analyzing the two reports, it became clear that there is a sizable difference in their conclusions."
Exact(2)
But in Maine, at least, there is a sizable difference between supporting L. L. Bean and supporting Linda Bean.
Though the Forward Backward score function and the SSB method produce comparable results in terms of accuracy, there is a sizable difference in the time it takes to update the weights using these methods.
Similar(57)
Although there was a sizable difference in the AWI score between participants with and without a history of gangrene and/or amputation, the difference was not significant, likely due to the small number of participants with this condition.
There is a sizable Turkish-speaking minority.
There is a sizable portion who stay in the Bahamas.
Sure enough there is a sizable collection of Van Gogh prints.
About a third is Roman Catholic, and there is a sizable Jewish minority.
The movement is new, but there is a sizable constituency for it.
The army is by far the largest component, and there is a sizable reserve force.
Clearly there is a sizable blast originating somewhere near the back seat.
But there is a sizable gulf between Graeber's anthropological insights and his utopian political prescriptions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com