It uses a Bayesian genotype likelihood model to estimate simultaneously the most likely genotypes and allele frequency in a population of N samples, emitting an accurate posterior probability of there being a segregating variant allele at each locus as well as for the genotype of each sample.
Since the lines derive from the same founder, and over-express the mRNA and total protein to the same extent, we suggest that there is an independently segregating variant allele of a gene involved in the proteolytic processing of TRAP.
The explanation could be that the selective constraint is low (many amino acid mutations are neutral) and/or that there is a high segregating load in this species (many slightly selected mutations segregate in the populations).
Suppose there is a putative QTL segregating with two different genotypes Qq (coded by 1) and qq (coded by 0) in the assumed backcross that affects the shape of TPCs.
There is a difference between segregating population variants (e.g. fast runners and slow runners, chocolate lovers and chocolate haters) and creating a self-consistent classification.
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Although there is a set of QTLs segregating only in hybrid poplar TD1 (see also), 16 the intercross model also finds those QTLs that are heterozygous in both maternal parent TD1 and paternal parent D2.
For carriers of balanced structural chromosome rearrangements, particularly reciprocal or Robertsonian translocations, there is a high risk of segregating unbalanced combinations of the normal and derivative chromosomes in meiosis, which can result in infertility, repeated miscarriage, or affected live births depending on the chromosomes involved and the size of the translocated segments.
The cluster 3 strain had a higher than expected average allele frequency for synonymous segregating sites, suggesting that there is a deficiency of low-frequency segregating alleles in this population.
All Dalmatians are homozygous for the Piebald, Ticking, and Flecking loci (or they would not display the classic spotting pattern) complicating characterization of these loci through standard techniques, such as linkage analysis, since there is not a segregating phenotype to detect.
There is a tendency for beads to segregate at the surface at low temperatures, similar to the study by Mansfield and Theodorou [35] in which Monte Carlo simulations were used to predict strong temperature-dependent structural properties.
