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Collectively, these results indicate that there exists substantial positive crosstalk between the WFS1 and AATF signaling pathways and lack of WFS1 mediates a self-perpetuating cycle of cell death.
Figure 1 shows that there exists substantial variation across countries in the share of labor allocated to small plants.
Tobacco use has been implicated in the etiology of a large number of cancers, and there exists substantial biological plausibility that it could also be involved in breast carcinogenesis.
Column (1) shows that there exists substantial variation across countries in the unemployment rates2 for youth below 25 years, ranging from 8% in Germany to over 40% in Italy, Spain and Greece.
Considering the fact that invasive FFR was originally validated against SPECT MPI [25] and that there exists substantial mismatch between invasive FFR and SPECT [26], the direct comparison between CCO decrease and SPECT MPI extends our understanding of CCO decrease as a clinical tool.
To this point, the empirical evidence of this investigation has shown that employment effects are relatively small, and, importantly, that there exists substantial sensitivity of estimates with respect to the choice of time period, polynomial trend specification, and trend filter methods.
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During PCR amplification there exist substantial risks of carryover contamination, particularly by previously generated amplicons.
In addition to the experimental studies, there exist substantial amount of theoretical studies to explain IBS-induced ripple formation.
Despite these efforts, there exist substantial challenges to achieving universal coverage of child immunization in developing countries, especially within the Sub Saharan African (SSA) region [31].
On the other hand, studies such as Awasthi et al. [7], Babirye et al. [8], and Egondi et al. [19] report that in spite of the physical access to health facilities and immunization centres in urban areas, there exist substantial barriers to immunization coverage in urban settings, with large underserved populations in slum and informal settings.
The species is known for its central role, and yet there exist substantial uncertainty regarding its precise interactions in the biochemical network (Kuepfer et al., 2007).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com