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During PCR amplification there exist substantial risks of carryover contamination, particularly by previously generated amplicons.
Thus, there exists substantial cross-talk between IGF-IR and HER2 in trastuzumab-resistant cells.
There exists substantial variability between calibration periods, again best expressed through predictive distributions.
There may exist substantial inappropriate blood product transfusion in the treatment and resuscitation of trauma patients.
There also exists substantial practice variation in HCT.
While for most candidates these would be substantial drawbacks, Ted Cruz is not most candidates.
There exist some drawbacks with local regions.
However, there exist several drawbacks.
There exists a substantial body of fire ecology literature for these ecosystems.
(b) There exists a substantial base of knowledge regarding power reactor siting, design, construction and operation.
There exists a substantial diversity of test case generation strategies for random testing binaries.
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