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During PCR amplification there exist substantial risks of carryover contamination, particularly by previously generated amplicons.
There exists substantial variability between calibration periods, again best expressed through predictive distributions.
Thus, there exists substantial cross-talk between IGF-IR and HER2 in trastuzumab-resistant cells.
There may exist substantial inappropriate blood product transfusion in the treatment and resuscitation of trauma patients.
Despite nationwide curriculum standards, there exists a substantial disparity between test results of examinees from big cities and those from rural areas.
There also exists substantial practice variation in HCT.
(b) There exists a substantial base of knowledge regarding power reactor siting, design, construction and operation.
There exists a substantial body of fire ecology literature for these ecosystems.
Similarly, the state is precluded from transferring individuals to another state where there exists a substantial risk of torture.
There exists a substantial diversity of test case generation strategies for random testing binaries.
Several studies indicate that MEK1 signaling increases paracellular permeability, there exists some disparity in observed cellular responses.
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