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"there are two main differences" is a correct and usable phrase in written English.
You can use it when you want to introduce a comparison between two things or concepts and highlight the fact that there are two major distinctions between them. For example: There are two main differences between cats and dogs: their behavior and their preferred living environment. In this sentence, the phrase "there are two main differences" is used to introduce the two distinct and important differences between cats and dogs, which will likely be discussed further in the following sentences.
Exact(41)
There are two main differences.
There are two main differences in the Spurs' improvement: their health, an issue in the last two postseasons, held up through the regular season; and Tony Parker and Manu Ginobili can strike fear in any opposing coach.
This is what I did sort out: there are two main differences in online help sites — those that allow a student to interact with a tutor through instant messaging and those that provide resources and techniques to help a student figure out answers to questions.
But there are two main differences.
There are two main differences between Meetro and RadiusIM.
However, there are two main differences comparing with [22].
Similar(19)
There are three main differences: (i) the raw data for the 10% share between 1810 and 1920 looks slightly different (as Giles discussed in his blog post, Piketty seems to have made slight errors in the wealth statistic for 1870 and inserted an additional data points for 1910) but this does not change the overall pattern of the graph significantly.
But there are three main differences.
There are three main differences between this paper and the 2008 version of the paper.
There are three main differences while comparing DSMS with the DBMS.
There are three main differences between the two cases (positive and negative values of both α and ϵ).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com