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I don't think there are defective generations.
Just like there are defective products out there, there are "defective" experiences in here: unhappiness, alienation, resignation, depression, hopelessness, resentment, shame, remorse, loneliness, dread and others.
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Preliminary studies from our laboratory suggest that in absence of both of these cytokines there is defective up-regulation of master transcriptional factors, T-bet and Eomes in CD8+ T cells (Figure S5).
"The committee is, of course, always concerned when there is defective workmanship under a government contract," said David Marin, the panel's staff director, though he noted that Parsons was addressing the problems through its subcontractor.
In PKU, there is defective hydroxylation of phenylalanine to produce tyrosine.
Therefore, if there is defective monocyte trafficking, it is unlikely to result from cell-autonomous effects of Slfn4-expressing monocytes, since this transgene is also UAS-dependent.
In pre-eclampsia, there is defective early trophoblastic invasion of the decidua due to failure of conversion of the spiral arteries into low-resistance channels.
Protein expression of PTEN was preserved, but there was defective regulation of PTEN function by the α2β1-polymerized collagen interaction.
These repeating elements in genes can be prone to a high rate of mutation if there is defective mismatch repair.
Strikingly, when patients with RA were treated with chemotherapeutic regiments, there was defective recovery of both CD4 and CD8 T cell populations, including both naive and memory cells.
Moreover, the normal fibrillar structure of fibulin-5 was disrupted in the lungs and aortas of both Ltbp-4-deficient mice and replaced by scattered amorphous patches, suggesting that there is defective deposition of fibulin-5 into the ECM (supplementary material Fig. S6B).
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