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Therefore, it has been reported that post-therapy decrease of Ktrans should at least be in the 30 50 % range to represent a significant therapy-induced change, whereas for ADC at DW-MRI a change of 10 20 % would be sufficient [15].
Future research will focus on establishing a cut-off point in the therapy-induced change of SUVmax to discriminate nodal responders from non-responders.
Acetylcholine-evoked responses were positively correlated to therapy-induced change in serum oxidation susceptibility in the dilated segment group (r2=0.56, P=0.006).
When comparing instruments measuring similar health constructs, an instrument sensitive to health differences among subjects is also likely to be sensitive to therapy-induced change as well.
For this study, we report on performance on the Sounds-in-Words subtest; raw scores are analyzed for therapy-induced change.
Similar(55)
We used commercially available, human iPSC-derived cardiomyocytes from a "healthy" female individual, treated with clinically relevant ERBB2 targeted therapies, trastuzumab and lapatinib to identify early therapy induced changes.
The dependence of the MRI biomarkers on a number of physiological factors points to the need to consider the biomarker changes in relation to one another to properly interpret the therapy induced changes.
Indeed, we found that IFN-ß therapy induces changes in gene interactions related to T cell proliferation and adhesion, although these gene interactions were not restored to levels similar to controls.
It also indicates the importance of measuring the whole spectrum of MRI tumor biomarkers and examining their changes in relation to one another in order to properly assess the therapeutic response and identify and interpret the therapy induced changes in the tumor physiology.
Levodopa therapy induced changes in T lymphocytes proteome [ 87].
55 Interferon-beta therapy induces changes in B-cell functioning that alter antigen presentation.
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