Sentence examples for therapy trail from inspiring English sources

As a result of successful antiretroviral therapy TRAIL is down-regulated, and there are fewer TRAIL-sensitive cells.

Because treatment with TNF is associated with strong systemic toxic side effects, the cytokine TNF-related apoptosis inducing ligand (TRAIL) has evolved as the most promising alterative for cancer therapy (TRAIL induces apoptosis in tumor cells while leaving non-transformed cells mostly unaffected) [ 8- 10].

Stem cell implants for cancer therapy: TRAIL-expressing mesenchymal stem cells target cancer cells in situ.

The finding may explain why anti-angiogenic cancer therapy trails are facing serious challenge [25].

Next, we used CT26 lung metastasis mouse model to determine whether combined therapy of TRAIL and CTL adoptive transfer is more effective in suppressing established lung metastases than single agent therapy.

While Akt inhibitors are not yet clinically available, our results suggest that ATO, an already approved medication, can achieve the same effect and offers a combination therapy with TRAIL as a novel systemic therapy for leukaemias.

Therefore, the deficient activation of caspase-9 might contribute to the clinically known resistance of human RCC against IR and also argues against an effective combination therapy with TRAIL and IR in this tumour type.

Low DR4 mRNA expression was observed, in concordance with our results, suggesting that combination therapies of TRAIL receptor agonists with fenretinide or chemotherapeutic drugs would be a better therapeutic regime for the treatment of paediatric tumours because of the upregulation of DR or downregulation of antiapoptotic factors.

This may happen soon through collaboration of diverse scientific groups, making the selection of targeted epigenetic aberration(s) more rapid, the design and probe of drug candidates, accelerating in vitro and in vivo assays, and undertaking new cancer epigenetic-therapy clinical trails.

Previous study suggests the sensitivity to TRAIL therapy was not closely associated with the expression levels of TRAIL receptors in some types of cancer.

In our prove of concept study, we demonstrated that tumor-specific CTL adoptive transfer immunotherapy, when combined with TRAIL therapy, achieved significantly greater metastasis suppression efficacy against the TRAIL-resistant colon carcinoma than either therapy alone (Fig. 7C).