The most urgent ATS 1 category was even less compliant than the ATS 2 category, perhaps more focused on airway, breathing and circulation rather than compliance with the antimicrobial therapy timelines.
Equally striking has been the rapid development of targeted therapies compared to the timeline for cytotoxic therapies, best exemplified by the development of ALK inhibitors for lung cancer, which took less than 5 years from initial identification of the EML4-ALK rearrangement as a molecular biomarker to clinical approval of the drug.
These concerns can constrain initiation of treatment for all women with indicated need, or may impede sustaining therapy over the recommended timeline established for the particular regimen, once treatment has been initiated [ 15, 16].
We don't know the molecular basis for the disease, and, with so much ground to cover, a correlative approach to research may hasten our timeline to therapies.
Therefore, wait times to a medical oncology consultation may adversely affect timelines of radiation therapy administration (see Rayson et al, in press).
19 All participating doctors and nurses were already using a local guideline for hypertension management derived from national hypertension guidelines 19 but were given additional guidance on timelines for escalating therapy.
As a proof-of-concept study it demonstrated that by linking several smaller, peripheral 'spoke' hospitals with a centrally located, PCI-capable 'hub' hospital, the use and timelines of reperfusion therapy could be improved.
The regulatory environment is among the many factors contributing to the need for firms developing cell therapies to persevere through a lengthy developmental timeline.
In this study, antimicrobial therapy was not compliant with the sepsis guideline timeline.
However, several publications report on targets and timelines that were used as thresholds before escalating therapy.
However, 2 months may not be a relevant timeline regarding pain after breast cancer surgery as adjuvant therapies will continue longer.
