Exact(2)
Table 1 Patient's demographics, clinical details, and previous treatments Case Age Sex History Diagnosis Previous therapy Reason for sirolimus 1 67 M Panuveitis OU with CME OD > OS treated with topical steroids.
For each DMARD course, the dosage, duration of therapy, reason for discontinuation (if applicable) and values for erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP) at the beginning, during the first year and at the end of therapy were recorded as surrogates of disease activity.
Similar(58)
Data were collected on diagnosis, disease duration, dates of therapy, reasons for treatment discontinuation, and AEs and serious AEs.
Five remain on therapy; reasons for drug discontinuation were disease progression (17), refusal (6), AE (3) and physician discretion (1).
A total of 785 patients [mean age 41.3 (11.5) years; 70.3% women] had the intake consultation but decided not to start therapy: reasons given for this included, only wanting the consultation and/or a diagnosis and/or some advice, referred to another specialist (e.g. psychologist, orthopaedic surgeon), decided not to come, travel distance too far, and unknown reasons.
In a recently published internet-based survey of 1595 patients with UC receiving 5-ASA therapy, reasons for poor compliance included forgetting to take medication (stated by >90% of patients), "too many pills", "dosing required too many times each day", "medication too inconvenient" and "no symptoms present", 19 confirming the results of previous studies.
In the current study RBC-AC was the most efficacious first line therapy, the reason for the apparent superiority compared PPI-triple therapies is not clear.
4 In contrast, although many patients will relapse with disease resistant to paclitaxel therapy, the reason for and role of paclitaxel resistance are still unclear in ovarian carcinoma.
Unfortunately, one-third of high-risk women will have a recurrent spontaneous preterm birth despite 17-alpha hydroxyprogesterone caproate therapy; the reasons for this variability in response are unknown.
Analogous to HIV therapy, we reasoned that the combination of HCV entry inhibitor with different classes of anti-HCV reagents may offer benefits over each single monotherapy.
Patients (n = 18) who violated the protocol or discontinued infliximab therapy (for reasons other than non-response) were excluded.
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