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Monitoring should also include a weekly laboratory workout and observations of the changes over time of these variables (Table 2).> -wrap-foot> C-reactivective protein; CRRT, continuous renal replacement therapy; ?, on demand in patients considered at risk.
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Continuous maintenance therapy with PPIs is the standard of care for severe GERD, but some patients may respond to intermittent short courses of PPI therapy given "on demand" when symptoms recur.
Observed MRI scores depended on patient age (age at initiation of FVIII prophylaxis and current age) and therapy regimen (prophylaxis or on-demand therapy).
Recent studies have examined the possibility of intermittent therapy with PPIs, also known as "on-demand" therapy, in patients with nonerosive reflux disease or mild esophageal mucosal inflammation.
The mean time to achieve maximum plasma activity after administration was 0.5 h in adults receiving individual replacement therapy, 1 h in adults receiving on-demand therapy, and 0.6 h in children.
Although the mean doses applied were similar between groups, the reported mean half-lives of plasma C1-INH were 31.5 h in children, 33.3 h in adults receiving replacement therapy, and 47.8 h in adults under on-demand therapy.
Low-dose proton pump inhibitors (PPIs) are often administrated as maintenance therapy for gastroesophageal reflux disease (GERD) and on-demand PPI therapy is a viable option for long-term management of GERD.
The majority of bleeding episodes occurred in joints (572 during on-demand therapy and 171 during prophylaxis) vs. other non-joint anatomical locations (57 during on-demand therapy and 25 during prophylaxis).
It should be noted, however, that on-demand therapy as defined in these trials is not in keeping with patients' conception of as-needed therapy.
The authors concluded that on-demand therapy may be effective in a substantial number of patients.
Lind and colleagues48 performed a large randomized controlled trial of on-demand therapy in 424 patients with nonerosive GERD.
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