Prior to developing adaptive immunity and gaining access to therapy, malaria-infected children depend upon host attributes that optimize parasite clearance or mitigate lethal pathophysiology (Stevenson & Riley, 2004).
Despite substantial progress in the control of Plasmodium falciparum infection due to the widespread deployment of insecticide-treated bed nets and artemisinin combination therapies, malaria remains a prolific killer, with over half a million deaths estimated to have occurred in 2013 alone.
After the training, the VHT members were equipped with medications, including artemisinin combination therapy for malaria and rectal artesunate for severe malaria, amoxicillin tablets for pneumonia, and oral rehydration solution and zinc for treating diarrhea.
This expansive range allowed us to observe a significant, negative association between case management with artemisinin-based therapy and malaria incidence while controlling for other primary malaria interventions.
9– 11 Recognizing the key role that accurate diagnosis plays in determining the cost-benefit of ACT as a first-line therapy for malaria, we conducted a pilot study to assess the accuracy of syndromic diagnosis for malaria in children made by healthcare workers in rural Sierra Leone and to determine what additional factors could be incorporated into the IMCI guidelines to improve malaria diagnosis.
They then go on to develop a photodynamic therapy for malaria using earlier findings about luminol enhancement from cancer chemotherapy and introducing artemisinin with its obvious relevance to malaria therapy.
And Brazil's state-funded researchers have devised some impressive drugs, including a new therapy for malaria (see article).
To report a side effect of quinacrine therapy for malaria.
Artemether lumefantrine is the most widely used artemisinin-based combination therapy for malaria.
Then White and his colleagues began a bruising, decadelong battle to get WHO to endorse ACTs as the first-line therapy for malaria worldwide. .
It acts as a global subsidy to provide greater access to combination therapy for malaria, particularly through private-sector drug retailers in developing countries.
