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Disease relapse is common upon therapy cessation, even in patients with complete molecular responses.
Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent reactivation following therapy cessation.
Although three patients showed reconstitution of peripheral lymphocytes within the predicted timeline, two patients continued to be lymphopenic 9 and 34 months after therapy cessation.
As per manufacturers' instructions, supplementation with folic acid (FA; folate) at a dose of 350 to 1000 μg daily should be started seven days before the first dose of pemetrexed-based chemotherapy and continued during therapy and for 21 days after therapy cessation.
Similarly, distribution of the proportion of patients experiencing viral rebound after therapy cessation was addressed (figure 3B).
Conversely, it cannot be fully excluded that the decreased levels of MsRNA-nef after therapy cessation may be explained by the "first peak" of viral replication in acute HIV-1 infection and its subsequent spontaneous decay independent of cART [69].
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Premature discontinuation of therapy was most frequent in the treatment arms containing IFN; the highest number of therapy cessations was observed in the 5-FU/LEV/IFN arm.
Higher toxicity and a higher frequency of premature therapy cessations resulted in a significantly lower cumulative 5-FU delivery in the IFN treatment arms, which could be a reason for the missing effect of IFN on DFS and OS.
Most importantly, these patient-reported outcomes are not fully implemented in today's clinical routine practice potentially resulting in therapy cessations and lower chemotherapy treatment rates for colorectal cancer especially in older patients.
Many of these toxicities are manageable and reversible with supportive therapies and/or cessation of cancer therapy.
Pyridoxine supplementation was given to all patients receiving antitubercular therapy until cessation of therapy.
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