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The idea of oral immunotherapy dates back to 1908, when a British doctor first reported desensitizing a child with an egg allergy to eggs by giving him small amounts of egg to eat over time, said Dr. Brian P. Vickery, the lead author of the paper, who was the lead scientist for the study and an employee of Aimmune Therapeutics while the trial was being carried out.
Understanding the function of the proteins encoded by these diverged genes may prove essential to a detailed appreciation of Bm-Bp-specific virulence and provide targets for therapeutics, while the in vivo expression data set as a whole provides a glimpse of the overall approach to life employed by these pathogens within the animal host.
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HOW THIS MIGHT CHANGE CLINICAL PHARMACOLOGY AND THERAPEUTICS ✓ While the PK data are specific to the chosen compound, the systems pharmacology model and the associated parameter estimates were obtained using existing biological knowledge and publicly available data.
In this sense vertical integration can be defined as the integration of fundamental pharmacology principles into clinical therapeutics while horizontal integration refers to the integration of these principles into a comprehensive and holistic view of patient care [ 17].
Drug delivery technologies have an important role to play in harnessing the power of immune therapeutics while avoiding on-target/off-tumor toxicities.
Excellent control over self-assembly behavior and structure allows for systematic determination of the role of important polymeric material properties (i.e., glass transition) on the release of model therapeutics while simultaneously controlling for size, dispersity, structural, and functionality effects.
Altogether, our data suggests that staged delivery of tumor-targeted therapeutics may provide an effective strategy to enhance the potency of toxin therapeutics while improving their safety profile.
Data from in-depth observations of the human genome are being used to inform the design and development of therapeutics while broad surveys of microbial communities are identifying new enzymes with biotechnological applications.
In developing new generations of coatings for medical devices and tissue engineering scaffolds, there is a need for thin coatings that provide controlled sequential release of multiple therapeutics while providing a tunable approach to time dependence and the potential for sequential or staged release.
The long half-life has made IgG the natural choice for engineering of antibody based therapeutics, while albumin is used as a fusion partner for or carrier of drugs.
This targeted strategy holds promise in paving the way for the introduction of highly effective nanoscopic vehicles for cancer therapeutics while overcoming drug resistance.
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