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MNPs should possess precisely tunable magnetic properties and biological functionalities for early diagnosis and efficient therapeutics, which could be achieved by tailoring the MNP size, shape, composition, and surface coating during chemical engineering processes.
Still oral therapeutics, which could either prevent tissue damage and/or support repair mechanisms are not available.
These results may reflect the lack of practical or case-based teaching approaches to therapeutics which could be more adequate for transition to postgraduate training than the frequently undertaken theoretical approaches.
The model system we have developed will be used to test these drug combinations as well as to further define mechanisms of sensitivity and resistance that may reveal additional therapeutics which could be used effectively with HDACi against aggressive DLBCL tumors.
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The administration of biological therapeutics can potentially elicit the development of neutralizing antibodies (NAbs) to the therapeutic drug in patients, which could have a significant impact on drug efficacy and safety.
Gene-silencing miRNA and siRNA are emerging as attractive therapeutics with potential to suppress any genes, which could be especially useful in combination cancer therapy to overcome multidrug resistant (MDR) cancer.
Development of high-performance cMAbs which could be used as therapeutics in exposed individuals is urgently needed to fill the current gap in defense against BWAs.
Further study of this phenomenon in different cell types under different conditions could help to identify factors responsible for regulating SMN1 expression, which could be targets for therapeutics development.
A series of 4-hydroxycoumarin derivatives were designed and synthesized as new acetylcholinesterase (AChE) inhibitors which could be considered for Alzheimer's disease therapeutics.
As such, there is great interest in the development of novel assays to interrogate these key pathways, which could lead to the development of novel therapeutics, and a better understanding of how DSBs are repaired.
12 The findings suggested that this increased expression potentially conferred an acquired pharmacoresistance, which could limit the bioavailability of ALS/CNS-targeted therapeutics.
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