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"When I started, therapeutics were not on my mind, but I think it's a natural evolution," he says.
GIP-based therapeutics were not developed alongside GLP-1 in the 1990s because early studies concluded that the peptide loses effectiveness in the diabetic state, perhaps secondary to receptor downregulation in the beta cell [ 7].
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Many of the molecular components in ischemia-reperfusion injury (IRI) have been identified, but effective therapeutics are not currently available.
The greatest cost in using animals to produce therapeutics is not creating the transgenic animals, but purifying the milk, which is a complex brew of fats and proteins.
Moving forward, aptamer therapeutics is not at a disadvantage.
The utility of NSAIDs in the cancer therapeutics is not limited to prevention strategies.
These have been experimentally used in clinical and animal studies, but their value in therapeutics is not proven.
This study has shown that the routine use of a non-rodent species in preclinical toxicology studies prior to initial clinical trials with cancer therapeutics is not necessary.
The pharmaceutical development pathway for cell-based therapeutics is not straightforward because it will require individualized expansion and manipulation of autologous cells under good manufacturing practice (GMP) conditions.
At present, adiponectin-based therapeutics are not available, partly due to difficulties in converting the full size adiponectin protein into a viable drug.
In the end, the main reason that therapeutics are not currently being developed to target for invasion and dissemination is the lack of relevant therapeutic end points and appropriate trial design in current clinical practice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com