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The surprisingly high incidence observed in common marmosets, which might be due to a limited variability in their major histocompatibility complex loci [ 11], allows the evaluation of the efficacy of therapeutics using a small number of animals.
Most importantly, this study investigated whether chemotherapy-induced MRP1 regulation can be inhibited with potential therapeutics, using a luminal breast cancer cell line (in accordance with the bias noted by Gonzalez-Angulo et al. to non-basal cancers) and an immortalised non-cancer breast epithelial line.
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The evaluation of cancer therapeutics using xenograft models is a resource-intensive and time-consuming endeavor.
Discovering the general potential of miRNA inhibitory therapeutics using LNA-based or similar platforms for a wide range of diseases is a major task for the future.
That study will have set the stage for an entire class of therapeutics, using bacteria as drug delivery systems and using the kinetics of bacterial growth as a mechanism for titrating therapy.
Here, we report a different TF-targeting therapeutics using fVII-conjugated photoactivatable SnCe6 for the treatment of chemoresistant human breast tumour.
Here, we prove that a P-gp/BCRP-driven pharmacoresistance limits the bioavailability of ALS therapeutics using riluzole, the only FDA-approved drug for ALS and a substrate of P-gp and BCRP.
A growing number of companies are currently developing an interest in producing therapeutics using IC-BEVS, and many products are today in clinical trials and on the market for veterinary and human applications.
There is a strong incentive to develop and validate cell therapeutics using allogeneic cells and/or tissues to treat chronic diseases and aging.
In the late 1980s, the National Cancer Institute (NCI) developed an in vitro drug discovery tool to test new therapeutics using 60 different human cancer cell lines [ 4].
Recent innovations in gene-based therapeutics using exogenous nucleic acids to modify gene expression in specific cells to treat pathological conditions have transformed its modern biomedical applications.
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