Amphotericin B and flucytosine are widely used for the treatment of cryptococcosis; however, the toxicity of both of these therapeutics is well described, and therapeutic failure is often observed [ 20].
Importantly issues in trial design by neurologists and other actions of the pharmaceutical industry destine therapeutics to failure and terminate basic science projects.
These findings define a novel function for BET proteins as signal-responsive regulators of cardiac hypertrophy, and suggest that small molecule inhibitors of these epigenetic reader proteins have potential as therapeutics for heart failure.
Pharmacokinetics, biodistribution, and biological activity are key parameters that determine the success or failure of therapeutics.
If this is causal of wound failure then therapeutics to enhance angiogenesis might produce good results, but might require more than the simple addition of vascular growth factors.
It has been used to describe observed clinical effects due to hyper- and hypoparathyroidism, anabolic and catabolic bone therapeutics, and progressive renal failure.
In that prior work, the model is described, with clinical effects due to hyper and hypoparathyroidism, anabolic and catabolic bone therapeutics, and progressive renal failure (more than 22 sets of observations) fit simultaneously.
Type 2 diabetes develops due to a combination of insulin resistance and β-cell failure and current therapeutics aim at both of these underlying causes.
MI survivors frequently develop heart failure; although many therapeutics in current use have proven beneficial, the high residual morbidity and mortality presents an urgent problem that requires a better understanding of the disease's pathophysiology.
Therefore, in the present study, we demonstrate the utility of dynamic contrast enhanced computed tomography (DCE-CT) and PET scanning to, firstly, longitudinally assess changes in muscle perfusion and metabolism as disease progresses in two murine models of DMD, and to, secondly, provide a baseline for monitoring the success (or failure) of various therapeutics.
