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The dynamic changes of systemic inflammatory biomarkers following exacerbations can be used to evaluate the therapeutics efficacy [ 5].
As with most other cancer therapeutics, efficacy is associated with side effects and in the case of RAF inhibitors, induction of secondary malignancies is a significant concern.
We have provided solid rationales for further clinical trials testing either examination of the bioenergetic propensity of HCC to predict the efficacy of sorafenib or activation of OXPHOS by PDK inhibitors as a measure of enhancing therapeutics efficacy of sorafenib.
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"We don't know enough about the pharmacology, the therapeutics, the efficacy of mitragynine," Goldberger said.
Although miRNAs are emerging as viable cancer therapeutics, their efficacy remains largely dependent on the development of effective delivery strategies.
Further investigation of compounds that increase chaperone burden or that inhibit the function of chaperones might lead to the discovery of new cancer therapeutics with efficacy in a broad spectrum of human tumors.
To determine which patient group (e.g., moderately or severely affected patients) benefits most from such therapeutics, their efficacy has to be tested in large animal models that resemble the clinical course and severity as closely as possible [ 4, 6, 21].
Targeting of nuclear receptors for therapy is a burgeoning field of medicine, with RXR therapeutics showing efficacy in clinical settings of cutaneous T cell lymphoma (Duvic et al., 2001; Khuri et al., 2001) and a preclinical model of Alzheimer's disease (Cramer et al., 2012).
Antibody-based therapeutics have shown efficacy alone and as components of effective therapies for an increasing number of human malignancies.
Although there are no specific therapeutics with proven efficacy, the majority of patients described had been treated with immunosuppressant therapy and a minority associated with recurrent infections with plaquinol.
Although several chemical agents, antibodies and vaccines are found to inhibit EBOV in animal or human, there is no therapeutics with high efficacy can be provided for clinical usage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com