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The gene-dosage therapeutic model relies on the identification of therapeutically relevant drug-gene interactions in which a clinically approved drug modulates mRNA and protein levels.
Human C-peptide concentrations and in vivo glucose responsiveness demonstrated therapeutically relevant glycemic control.
Lehar, J. et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity.
These findings establish alternative strategies to target EECs with therapeutically relevant hormone production through BMP modulation.
Lehár, J. et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity.
Transcranial magnetic stimulation: a historical evaluation and future prognosis of therapeutically relevant ethical concerns.
Imaging and cellular viability parameters allow structural cardiotoxicity to be detected at therapeutically relevant concentrations and facilitates molecular phenotypic insights.
Consequently, it is important to consider therapeutically relevant maximum total plasma concentrations (Cmax) when investigating drug-induced toxicity.
The remaining one compound, isoproterenol, was not predicted at therapeutically relevant concentrations of less than 100 times Cmax.
"These cells are not therapeutically relevant at the moment," Dr. Noggle said.
At therapeutically relevant concentrations, Z123212 did not cause significant motor or cardiovascular adverse effects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com