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We hypothesized that a synthetic cytokine linking GMCSF to MCP3 (hereafter GMME3) as part of a single polypeptide would acquire novel, therapeutically desirable immunomodulatory properties.
These agents act via a mechanism that modulates the Ca2+-sensitivity of troponin; such a mode of action is therapeutically desirable because intracellular Ca2+ concentration is not perturbed, preserving the regulation of other Ca2+-based signaling pathways.
4 5 It is this thermal effect that produces therapeutically desirable retinal lesions.
Intriguingly, the failure of hESCs to strive in old skeletal muscle might represent a therapeutically desirable outcome.
A breakthrough in the field has been achieved with the introduction of adeno-associated virus (AAV) vector systems, in particular the discovery of highly cardiotropic AAV serotypes and the reengineering of AAV with therapeutically desirable properties.
Also GLP-1 decreases gastric emptying rate and appetite [ 5, 7], properties that are therapeutically desirable given the association of type 2 diabetes mellitus with obesity, and the association of obesity with insulin resistance [ 8, 9].
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Undesirable desire turned desirable.
The release profile of the burst release for hydrophilic drugs could be therapeutically useful for antibiotics where a high dose is desirable initially.
Costing around 200 USD, our HLA haplotyping strategy has the potential to drastically reduce the capital investment required to populate clinical grade hESC banks with therapeutically relevant lines, by pre-selecting those embryos for derivation with desirable HLA phenotypes.
The capital investment required to populate clinical grade hESC banks with therapeutically relevant lines is therefore significantly reduced, by pre-selecting those embryos for derivation with desirable HLA phenotypes – hence addressing both the cost of treatment and the need to minimize immune rejection upon transplantation.
Heterogeneous populations of mitochondria between organs have been shown and might be therapeutically targeted (Jayakumar et al., 2007); in the same way, it might in the future be both desirable and possible to target specific cellular populations of mitochondria, the latter e.g. based on differences in their membrane potential.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com