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We've even reached a therapeutic milestone.
Although docetaxel represents an important therapeutic milestone and is the current standard of care for metastatic hormone-refractory prostate cancer (HRPC), most patients eventually progress because of clonal selection of therapy-resistant cells or the development of cells with a drug-resistant phenotype.
Although obtaining clinical response represents an important therapeutic milestone, it does not necessarily indicate a complete recovery from MDD, since many patients with clinical response will still be left with substantial residual symptoms of depression.
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However, critical review of actual literature shows that despite certain efforts a milestone in therapeutic success is up to date not in sight.
Encouraged by the recent milestone of therapeutic cure of chronic hepatitis C virus infection, significant academic and industrial efforts are now focusing on finding a cure for chronic hepatitis B. The review article by Chang and colleagues thoroughly analyzes the major obstacles for the functional cure of chronic HBV infection.
Such biomarker-guided therapeutic interventions may represent a milestone in the development of a personalized medicine in the ICU which is probably more relevant to the heterogeneity of critically ill patients.
Even acknowledging the current complexity of personalised treatments, it is broadly accepted that the information mandatory for inclusion in the pathology report represents a milestone for optimal therapeutic planning.
Therefore, the additional consideration of factors such as type and efficacy of and engagement in therapeutic intervention, the achievement of developmental milestones, socioeconomic state, as well as environmental contexts, might have reinforced prediction accuracy even more.
Moreover, utilizing established disease measures in canine models provide sensitive and specific milestones of disease progression and therapeutic response that parallels surrogate markers used in human patients.
"The study is a milestone in the search for new therapeutic targets for Alzheimer's," says Vanderbilt University pharmacologist Oliver Boutaud, an expert on the cyclooxygenase pathway who was not associated with the study.
The very recent approvals of gene therapeutic agents for the European market are a milestone in the field of gene therapy and raise hope for many patients suffering from orphan diseases as well as many other more common illnesses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com