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The excellent activity of anidulafungin has made this antifungal a first line therapeutic indication for candidemia and invasive candidiasis in non-neutropenic patients.
Therefore our data suggest a potential new therapeutic indication for GA in the treatment of prion-based disease in mammals, including in humans.
In the latter study, patients received treatment with a "dose-dense" chemotherapy regimen; if confirmed, the combined data may outline a therapeutic indication for aggressive dose-dense therapy based on tumor TP53/CHEK2 status.
International paediatric guidelines recognize a blood glucose of < 3 mmols/L, in children with severe disease as a therapeutic indication for treatment [ 24].
When PF543 was deployed both in in vitro and in vivo studies to inhibit SphK1, reduced sickling of red blood cells was observed, suggesting a possible therapeutic indication for sickle cell disease.
One successful example is sildenafil which was first developed to treat angina but whose another effect of prolonged penile erections in human volunteers led to a new therapeutic indication for the drug.
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Nowadays, therapeutic indications for cannabinoids, specifically Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) are widening.
Remarkably, this kind of approach has already led to the identification and experimental validation of novel therapeutic indications for the antiepileptic topiramate in inflammatory bowel disease (IBD) [6].
Drug repositioning or repurposing is a principle of discovering novel therapeutic indications for existing approved drugs, which provides an alternative and cost-efficient strategy of discovering disease therapeutics [36].
Since the use of BoNT for the treatment of strabismus was pioneered more than 40 years ago, the therapeutic indications for BoNT type A (BoNT-A) and, more recently, type B for treating excessive and/or undesired muscle tone, have progressively expanded [12].
We demonstrate that DRUGSURV validates therapeutic indications for known cancer drugs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com