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Importantly, most trials have important methodological flaws and have used inconsistent methods and therapeutic endpoints [29].
Furthermore, controversies regarding the appropriate therapeutic endpoints of EoE have impeded the design of clinical trials.
Comprehensive measurement and deconvolution of these potential biomarkers via multivariate analysis allows predictions of disease state and evaluation of therapeutic endpoints.
We also advocate close surveillance and treatment of HBV patients according to therapeutic endpoints [ 23].
Unfortunately, there are no data comparing the efficacy of different therapeutic endpoints in the clinical setting.
Importantly, most trials have important methodological flaws and have used inconsistent methods and therapeutic endpoints [ 29].
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PET/CT imaging was also used as a primary therapeutic endpoint for sorafenib, inhibitor of Raf kinase activity [19].
We, therefore, defined two therapeutic endpoint values, 130 and 135 mEq/L, which were reached after a median of 1 and 3 days, respectively.
Viruses have many properties that can be adapted to achieve this therapeutic endpoint; furthermore, they can be engineered to replicate selectively in cancer cells and lyse them.
In those reports, %T > MIC ranges from 25%to70%70 % for defined therapeutic endpoint [ 26– 28].
The use of histology as a therapeutic endpoint also leads to several potential pitfalls.
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