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We filtered the results of this exploration to keep only the pairs located on the protein surface as it is the most accessible location for known therapeutic targets (accessibility threshold greater than 25%, using the ASA software [ 26] and implemented by Allan et al. [ 27] based on the 3D PR structure PDB ID 1HSG [ 28] and 3D RT structure PDB ID 1DLO [ 29]).
Efforts should be made to improve the accessibility of therapeutic procedures for patients with UGIB in Nigeria and other low resource settings.
Seamless approaches to drug development in oncology hold great promise of accelerating the accessibility of novel therapeutic agents to the public but are also accompanied by important trade-offs, including the limited availability of information on the clinical benefit and safety of novel agents at the time of market entry.
Images about targeting known, non-biopsied lesions can confirm antigen expression and accessibility of the therapeutic dose.
Efforts should be made to improve the accessibility of these therapeutic procedure for patients with UGIB in Nigeria.
Logistical organization and accessibility to several therapeutic solutions can influence a physician's decisions regarding a trauma patient.
Past two decades have witnessed the accessibility of commercially available therapeutic products of protein and gene with the different kinds of delivery system.
Despite the accessibility to multimodal therapeutics including surgery, chemotherapy and radiation therapy, the overall therapeutic benefit against glioma remains unsatisfactory [ 5].
One of the greatest therapeutic challenges is gatekeeper mutation that change the accessibility of a hydrophobic pocket critical for the binding of small molecule TKIs (Zhang et al., 2009).
The approach has several important advantages over traditional inpatient therapeutic care, including earlier intervention, greater coverage, and increased accessibility.
In some Asian countries, accessibility to opioids is severely restricted, leaving little therapeutic alternatives for the treatment of serious pain.
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