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The maximum likelihood estimation (MLE) was applied to calibrate the parameters, and after a series of calibration, model evaluation, and theoretical modification of the model, the final model was established (Fig. 3).
Theoretical modification of the LE linker in the crystal structure of cpEGFP (PDB 3EVP) for either CP or FP using Pymol yields different rotamers.
4) On several occasions the authors refer to theoretical modification or replacement of residues in the structure and show new conformations and distance measurements, but the methodology used was unclear.
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Some empirical and theoretical modifications of an eight parameter equation of state, previously reported in this journal, are described.
Theoretical modifications of the linker sequence were performed using Pymol by replacing the linker residues LE of cpEGFP (PDB 3EVP) with GS.
21 Our work has shown how theoretical modifications to the properties of a drug (either by chemical alteration or pharmaceutical modification) can be quantified in terms of an alteration in forgiveness.
Given the overwhelming combinatorial complexity of theoretical histone modifications, we believe it reasonable that histone modifiers participate in crosstalk to engage a more tractable number of states.
The more frequent and less-theoretical the modification index induced changes, the greater the concern even if the model subsequently fits.
In theoretical refinement, a modification of existing theoretical perspectives is conducted (Edmondson and McManus (2007).
In conducting two-dimensional DNS the theoretical method requires modification to account for the radiation of the total pressure difference in two dimensions only, as opposed to the three-dimensional sound radiation originally considered by Amiet.
Misfitting models were re-specified guided by theoretical soundness and modification indices [55].
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