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Since then, aberrant miRNA expression has been implicated in the initiation and progression of numerous hematological cancers and solid tumors, including SCCHN [ 16– 16].
Since then, aberrant over-expression of COX has been consistently associated with malignant transformation of healthy tissue, proliferation and increased invasiveness of malignant tissue, and unfavorable clinical outcomes.
If DPRs are key to pathogenesis, then aberrant nuclear export of repeat RNA sequences, which is necessary to facilitate access to cytoplasmic translation machinery, may be an attractive therapeutic target.
Since then, aberrant overexpression of Bmi1 has been detected in several human cancers including lymphoma, acute myeloid leukemia, colorectal carcinoma, liver carcinoma, non-small cell lung cancer, breast carcinoma, prostate cancer, head and neck squamous cell carcinoma, medulloblastoma, and glioblastoma [ 14– 23].
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It seems so aberrant, so senseless, that we seek reasons.
Under such a system, if three judges cannot agree on a round, then the aberrant score is thrown out.
Then, the aberrant methylation signatures of these genes found in the metastatic lymph node can provide a further clue to establish useful biomarkers for screening metastasis in breast cancer.
Then an aberrant transposition event (abortive excision event) of this MULE caused a DNA double-strand break that enabled exonucleases to digest the unprotected DNA ends thereby extending the gap into the adjacent P1-wr repeat.
We then investigated whether aberrant TIMELESS expression was associated with tumor stage or prognostic outcome.
We then assessed whether aberrant clones were independently capable of initiating tumours in mice.
We then determined whether aberrant methylation might confer decreased expression of the Topo II α gene.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com