Other medicines as expensive as Avastin are typically prescribed only for rare conditions affecting small numbers of patients, and their makers justify the costs as necessary for getting a return on their up-front investments in the drugs.
While their up-front cost is lower than that of larger reactors, they might prove to cost more per kilowatt of capacity and per kilowatt-hour of power generated.
"It is totally vital to their up-front sales," one network executive said, referring to the advertising sales that take place in the spring, in which sponsors buy up the majority of network commercial time.
The federal Department of Housing and Urban Development is proposing rules for the closing process to discourage surprise costs and keep lenders to their up-front good-faith estimate.
Mr. Diller calls Paramount's cost-cutting efforts "pay as you go". Paramount, he said, "is lowering the cash up front but offering participation in the gross receipts of a movie". Several stars of Paramount movies in production, including Ryan O'Neal and Jill Clayburgh, have dramatically lowered their up-front salaries in return for up to 10percentt of their movies' gross profits.
Mr. Pheulpin, whose company built similar but much smaller programs in 10 other cities, like Lyon and Rouen, said the company had learned that there were several keys to success: allowing subscriptions, so people get the sense that the bikes are free once they have paid their up-front fee; making sure the bike stations are ubiquitous and keeping the system "user-friendly".
Luckily for Delta, their up-front investment in the refinery was relatively low.
The only thing you can count on when you do a credit derivative with a hedge fund is their up-front collateral.
However, the biggest pricing complaint wasn't due to their up-front cost, but, rather, Verizon Wireless's smartphone tax of $30 per month.
We also lease expensive equipment to businesses, reducing their up-front costs and eliminating the need for additional collateral -- minimizing risk for both the entrepreneurs and our loan fund.
For example, borrowers who have lots of equity in their home might be able to simply refinance with a less-expensive conventional loan and draw out some cash, reducing their up-front costs and saving on their overall finance charges.
