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Figure 1 illustrates the observed or predicted positions of several functionally relevant phosphosites on the high-resolution cryo-EM structure of human 26S proteasome (Huang et al., 2016), and their speculated roles in proteasome regulation are summarized in Table 1.
The exact mechanism of action of the wide variety of secondary antioxidants have not been properly understood but some of their speculated activities include chelating prooxidants or catalysts, providing hydrogen to primary antioxidants, decomposing LOOH to nonradical species, scavenging ground state and singlet oxygens, and absorbing UV light 22.
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Few players have seen their future speculated over more than Manly half-back Daly Cherry-Evans.
Keller, Koto, and their colleagues speculated that this excessive exercise might be responsible for the ants' rapid demise — perhaps the ants weren't eating enough to fuel their lengthy perambulations.
As these TCS may act as positive or negative regulators depending on their targets, we speculated that their inactivation would increase the transcription of genes weakly or not expressed in the WT strain under the conditions tested.
Most conclusions came from indirect evidence by using specific antibody or by analyzing their expression to speculate their role in human DCs migration.
We explain their choices by speculating about their social conditions, their confused identities, their hardships at home.
Their speculating on society and the human beings gave birth to philosophy and science, eventually introducing the very concept of politics, and ultimately democracy.
The man in the yellow shirt and the people inside the pen passed their time speculating on how pretty life might be across the blue barricade.
Last month the third installment of Thrilling Wonder Stories took place, where technologists, artists, futurists, and authors gathered together to let their imaginations speculate on what marvels the future may have in store for us.
On this count the researchers can only speculate, although their speculation is of the justified, data-backed sort.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com